Bacteria Organisms

Staph Aureus +ve Niche Main Infections Other Nose Skin/soft tissue, bacteraemia, bone/joint, endocarditi…

Doxycycline

Drug Class Tetracycline Mechanism Bacteriostatic - inhibit protein synthesis Typical Dose 500mg BD …

Animal bite antibiotics

  Prophylactic antibiotic dose should be given in human, dog + cat bites 1st line - co-amoxiclav 2nd line - doxycycline & metroni…

Gentamicin

Drug Class Aminoglycoside Mechanism Bactericidal  Typical Dose IV or drops only - 3-7mg/kg in 3 …

Antibiotic Classes

Cell wall synthesis inhibitors Beta lactams Penicillins - relatively narrow spectrum Cephalosporins Carbapenems Monobactams Glyco…

Antibiotic Spectrum Coverage

Clindamycin

Clindamycin is an antibiotic belonging to the lincosamide class, and it is commonly used as a second-line treatment for cellulitis when patients ar…

Azithromycin

Before starting baseline ECG and LFTs are required Azithromycin has been known to cause prolongation of the QT interval on ECGs in some patients, …

UTI in Pregnancy

UTI in pregnancy should always be treated even if asymptomatic First Trimester Trimethoprim should be avoided as it is teratogenic (fol…

Urinary Tract Infections

Uncomplicated Non pregnant Female  Normal urinary tract and kidney function 3 day course of antibiotics - nitrofurantoin (avoid with…

Hospital Acquired Infections

C. diff Treatment of a patient with antibiotics, PPIs eg, allows the bacteria to grow unregulated → symptoms Spore are released in …

Co-amoxiclav

Broad spectrum antibiotic - combination of amoxicillin and clavulanic acid (beta lactamase inhibitor) RTIs, UTIs, skin and soft tissue infection…

Amoxicillin

Drug Class Broad spectrum bactericidal penicillin Mechanism Inhibits bacterial cell wall synthesis by preventing cros…

Cephradine

Drug Class Cephalosporin Mechanism Attach to penicillin binding proteins to interrupt cell wall synthesis …

Trimethoprim

Drug Class Antifolate abx Mechanism Decreases bacterial folate production so bacteria cannot synthesise DNA …

Erythromycin

Drug Class Macrolide Mechanism Broad spec bacteriostatic abx - inhibits bacterial protein synthesis Typic…

Ciprofloxacin

Drug Class Quinolone Mechanism Broad spec bactericidal abx - inhibits DNA gyrase (needed to coil and replicate bacter…

Metronidazole

Drug Class Anaerobic antimicrobial Mechanism Broken down to toxic compounds within microbes with anaerobic…