Von Willebrand Disease

Most common heritable bleeding disorder - defect in quality or quantity of vWF. Each type or more severe Type 1 - quantitative defect, autosomal dominant Type 2 - qualitative defect, autosomal dominant Type 3 - no vWF produced

PT normal, aPTT $\uparrow \uparrow$ (transport FVIII so intrinsic pathway affected)

Treatment with DDAVP, TXA