#Antibiotic #Drug

Trimethoprim

evan April 13, 2024

Drug Class	Antifolate abx
Mechanism	Decreases bacterial folate production so bacteria cannot synthesise DNA
Typical Dose	200mg BD
Indications	UTIs (eg E coli) Prostatitis
Contra-indications	Pregnancy Severe renal impairment Blood disorders
Side-effects	Rarely: bone marrow suppression, N&V, rash, toxic epidermal necrolysis
Interactions	Cyclosporins: increased risk of nephrotoxicity Pyrimethamine: increased antifolate effects
Elimination
Additional Notes	Resistance is common