The Hemophilias

• X linked disorders so typically expressed in males, carried by females (but can show some symptoms rarely)
• Severity is consistent between family members

Haemophilia A - Factor VIII deficiency (aPTT)

Haemophilia B - Factor IX deficiency

More severe bleeding than vWF

Rx with replacement clotting protein, DDAVP - Emicizumab - mimics FVIII