| Drug Class |
Thrombolytic |
| Mechanism |
- Binds to circulating plasminogen forming activator complex
- Converts plasminogen to plasmin
- Plasmin lyses fibrin within thrombus
|
| Typical Dose |
250,000 units then 100,000 units every 1 hour for 24 hours or 1,500,000 units over 1-2 hours |
| Indications |
- Acute MI (when PCI is over 2 hours away)
- Thromboembolic events: DVT/PE/central retinal thrombosis
|
| Contra-indications |
- Recent haemorrhage/trauma/surgery
- Coagulation defects
- Aortic dissection/aneurysm
- Acute pancreatitis
|
| Side-effects |
- Nausea/vomiting
- Bleeding
- Hypotension
- Allergy
- Reperfusion arrhythmia/cerebral oedema
|
| Interactions |
Warfarin - increased risk of bleeding duh |
| Elimination |
|
| Additional Notes |
Body generates antibodies to streptokinase so cannot be used twice in the same year. Should be given within 12 hours of MI, best effect within 3 |
ALPHA