#Cardiovascular #Drug

Spironalactone

evan April 8, 2024

Drug Class	Potassium sparing diuretic
Mechanism	Aldosterone antagonist Competes for receptors in DCT cells Inhibition of Na retaining action Decreases potassium secreting effect
Typical Dose	25-50mg or 100-200mg OD
Indications	Oedema/ascites in liver cirrhosis Nephrotic syndrome CCF Primary hyperaldosteronism
Contra-indications	Hyperkalaemia/hyponatraemia Addison's disease
Side-effects	GI disturbance Impotence Gynaecomastia Menstrual irregularities Lethargy/headache/confusion
Interactions
Elimination
Additional Notes