#Drug #Respiratory

Salbutamol

evan April 9, 2024

Drug Class	β2 agonist
Mechanism	Stimulates β2 receptors in the airways generating cAMP ↓ intracellular calcium - bronchodilation prevents mast cell degranulation (inhibits uterine smooth muscle contraction in premature labour)
Typical Dose	2.5-5mg (nebulised)
Indications	Asthma COPD with reversible component Premature labour
Contra-indications	Hyperthyroidism Cardio disease - arrhythmias HTN Caution in diabetes (risk of DKA in IV)
Side-effects	Common: tremor, tachycardia Rarely: headache, palpitations, hypokalaemia, muscle cramps, insomnia
Interactions	Corticosteroids: high doses of both increase risk of hypokalaemia Loop/thiazide diuretics: increased risk of hypokalaemia Theophylline: increased risk of hypokalaemia
Elimination
Additional Notes	Plasma potassium needs to be monitored if given severe asthma. <8y/o need a spacer/nebuliser. Preferred to ipratropium