#Cardiovascular #Drug

Ramipril

evan April 8, 2024

Drug Class	ACE inhibitor
Mechanism	Inhibits angiotensin converting enzyme - ↓ angiotensin II synthesis and ↑ bradykinin accumulation
Typical Dose	2.5mg - max 10mg daily
Indications	HTN HF Post-MI Diabetic nephropathy
Contra-indications	Renal vascular disease (renal artery stenosis) Aortic stenosis Pregnancy (unless essential)
Side-effects	Common: postural hypotension, dry cough (switch to ARB), rash Rarely: hyperkalaemia, decreased renal function
Interactions	Diuretics - pronounced hypotension Lithium - increased concentration NSAIDs - risk of renal impairment K-sparing diuretics - risk of hyperkalaemia
Elimination
Additional Notes	Patients should take 1st dose before bed to avoid 1st dose hypotension.