#Drug #Gastroenterology

Omeprazole

evan April 8, 2024

Drug Class	Proton pump inhibitor
Mechanism	Inhibits gastric acid secretion by dose-dependent inhibition of proton pump of gastric parietal cells (blocks H+/K+ pump ATPase enzyme in parietal cells)
Typical Dose	20-40mg OD
Indications	GORD dyspepsia Oesophagitis GI ulcers H. pylori eradication Zollinger-Ellison syndrome (gastrin-secreting tumour or hyperplasia of the islet cells in the pancreas)
Contra-indications	Caution in: Liver disease Breast feeding/pregnancy
Side-effects	GI disturbances Headache Long term use associated with hypomagnesemia
Interactions	Inhibits cytochrome P450 ↑ plasma concentration of phenytoin, warfarin
Elimination	80% renal, 20% faecal
Additional Notes	May mask symptoms of gastric cancer