ALPHA
Where is blood made in utero
- Day 18 to 3m in yolk sac
- 3m to 6m liver and spleen
- 6m onward bone marrow
Haemoglobin:
\(\alpha^2\) + \(\gamma^2\) = Fetal Hb
\(\alpha^2\) + \(\beta^2\) = Adult Hb
\(\alpha^2\) + \(\delta^2\) = HbA\(_2\)
How do RBC differ in neonates
- Different Hb (Hb-F completely gone by 6 months)
- Polycythaemic
- \(\uparrow\) reticulocytes
- \(\uparrow\) nucleated RBCs - gone after 3-4 days, if still present after indicates baby struggled in womb/placental hypoxia