#Drug

Morphine

evan April 13, 2024

Drug Class	Opiate
Mechanism	Mimics endogenous opioids, acting on opioid receptors
Typical Dose	10mg every 4 hours - adjusted according to response
Indications	Severe pain Acute pulmonary oedema due to HF Intractable cough
Contra-indications	Severe respiratory disease (depressant) ↑ ICP and head injury (changes pupil response for neuro obs) Undiagnosed acute abdomen Acute alcohol intoxication (depressant) Hepatic failure
Side-effects	N&V, drowsiness, constipation, dry mouth, respiratory depression Dependance
Interactions	Hypnotics: enhances sedative effect
Elimination
Additional Notes	Effects can be reversed with naloxone. Tolerance begins after 2 weeks of continuous use - after which dose should be increased