#Antibiotic #Drug

Metronidazole

evan April 13, 2024

Drug Class	Anaerobic antimicrobial
Mechanism	Broken down to toxic compounds within microbes with anaerobic/microaerophillic metabolism Toxic compounds kill microbes by interfering with nucleic acid function and synthesis
Typical Dose	400mg TDS
Indications	Anaerobic protozoal infections Dental infections Helicobacter pylori eradication Rosacea Pseudomembranous colitis Foot infection etc etc
Contra-indications	Caution: pregnancy, breastfeeding, hepatic impairment Avoid exposure to strong sunlight/UV
Side-effects	Dry mouth, myalgia, nausea, oral disorders, metallic taste
Interactions	Alcohol: causes disulfiram-like reaction (flushing abdo pain hypotension). Must be avoided Warfarin & Phenytoin: increased plasma conc
Elimination
Additional Notes	Therapeutic monitoring for course >10 days. Commonly used to treat dental infections