Memorising the leukaemias

Children

T-blast TdT+

B-cell blast = TdT+ & CD10+

Philadelphia chromosome t(9;22) (CreaM cheese → philadelphia)

Tx: imatinib (tyrosine kinase  inhibitor)

CML can undergo a blast crisis and become AML

Auer rods

Myeloperoxidase positive

aLL-trans retinoic acid

> 60 years

"Crushed little lymphocytes" → smudge cells on peripheral smear