Maturity-Onset Diabetes of the Young

Maturity-onset diabetes of the young refers to any of several hereditary forms of diabetes mellitus caused by mutations in an autosomal dominant gene disrupting insulin production.

• Usually strong family history as autosomal dominant unless de novo mutation
• Typically non-obese and have normal or low body mass index (BMI)
• Glimepiride, a sulfonylurea, stimulates insulin secretion from pancreatic beta cells and can be effective in some types of MODY
• Individuals with MODY generally have some endogenous insulin production preventing DKA under most circumstances