#Drug #Gastroenterology

Loperamide

evan April 8, 2024

Drug Class	Anti-diarrhoeal agent
Mechanism	Acts on opioid receptors in myenteric plexus to inhibit peristalsis (inhibits ACh release)
Typical Dose	2-4mg OD up to 16mg in 2 doses
Indications	Acute & chronic diarrhoea Faecal incontinence
Contra-indications	Active ulcerative colitis Abx-associated colitis Dysentery
Side-effects	GI disorders (abdo cramps) Headache Nausea
Interactions	Desmopressin
Elimination
Additional Notes