#Drug #Neurology

Lamotrigine

evan April 12, 2024

Drug Class	Anti-convulsant
Mechanism	Binds and inhibits voltage-gated sodium channels, stabilizing presynaptic neuronal membranes and inhibiting presynaptic glutamate and aspartate release
Typical Dose	25mg for 14 days then 50mg for 14 days then increase by 100mg every 7-14 days
Indications	Partial seizures Tonic-clonic seizures Focal seizures Bipolar disorder Trigeminal neuralgia
Contra-indications	Cautions: Brugada syndrome, Parkinson’s disease, Myoclonic seizure (exacerbating)
Side-effects	Common: Rash, agitation, sleep disorders, tremor, N&V
Interactions	Ritonavir: decreases the exposure to Lamotrigine
Elimination
Additional Notes