#Cardiovascular #Drug

Isosorbide Mononitrate

evan April 8, 2024

Drug Class	Nitrate
Mechanism	Metabolised to NO in smooth muscle cells Causes vascular smooth muscle relaxation Coronary artery/systemic vein vasodilation
Typical Dose	20-50mg OD
Indications	Angina prophylaxis HF
Contra-indications	Hypotension Aortic/mitral stenosis Contrictive pericarditis Hypertrophic obstructive cardiomyopathy Head trauma/cerebral haemorrhage
Side-effects	Headache, dizziness, postural hypotension, flushing, tachycardia
Interactions	Sildenafil - ↑ hypotensive effects
Elimination
Additional Notes	Tolerance can occur after 24hrs, minimise this by allowing drug-free period of 8 hours