Hypercalcaemia

Mild

• Polyuria, polydipsia
• Mood disturbance
• Nausea, fatigue constipation
• Anorexia

Severe

• Abdo pain
• Coma
• Pancreatitis
• Cardiac arrhythmias - isolated QTc shortening

 

Non-PTH mediated - PTH low/suppressed, vitamin D intoxication, chronic granulomatous disorders, thiazide diuretics

PTH-mediated - high PTH, primary hyperparathyroidism

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Stones - renal stones due to hypercalciuria

Bones - bone pain and osteoporosis due to inappropriately high PTH

Moans - lethargy, fatigue, depression

Groans - abdominal pain, constipation, nausea, vomiting