| Drug Class |
Sulphonylurea |
| Mechanism |
- Stimulates insulin production in pancreatic β cells - therefore only effective when some β cell activity is present
- Causes depolarisation and insulin release
- Also inhibits gluconeogenesis
|
| Typical Dose |
40-80mg |
| Indications |
|
| Contra-indications |
- Ketoacidosis
- Pregnancy/breast feeding
- Caution in those susceptible to hypos
|
| Side-effects |
- Hypoglycaemia
- Weight gain
- Rarely: bone marrow suppression
|
| Interactions |
|
| Elimination |
|
| Additional Notes |
Often combined with metformin as a duotherapy |
ALPHA