#Antibiotic #Drug

Erythromycin

evan April 13, 2024

Drug Class	Macrolide
Mechanism	Broad spec bacteriostatic abx - inhibits bacterial protein synthesis
Typical Dose	250-500mg QDS
Indications	Alternative to penicillin Gram +ve (and some gram -ve) infections Mycoplasma pneumoniae, legionella. chlamydia, acne, rosacea
Contra-indications	Liver disease Caution: in electrolyte disturbances (pre-disposition to QT interval prolongation)
Side-effects	Common: N&V, diarrhoea, rash phlebitis Rarely: reversible hearing loss, QT prolongation
Interactions	Inhibits hepatic drug-metabolising enzymes - so increases exposure to: Antihistamines Cyclosporin Digoxin Theophylline Warfarin
Elimination
Additional Notes	>14 days ox Abx increase risk of hepatic damage