ALPHA
#Neurology

Epilepsy

evan Feb. 23, 2024
Seizure type Location Before During After Treatment
Generalised tonic-clonic seizures (grand mal) General brain Aura Tonic (muscle tensing), Clonic (muscle jerking). Tonic before clonic usually. Incontinence, tongue biting, complete LOC Post-ictal peroid - confused tired irritable and low

Sodium valproate

Women able to have children - lamotrigine or levetiracetam

Focal seizures (partial seizures) Can be anywhere localised Deja vu, strange sensations Aware in simple partial seizure but not in complex   Lamotrigine or levetiracetam 
Myoclonic seizures     Sudden brief muscle contractions - jolt  

Sodium valproate

Women able to have children - levetiracetam

Tonic seizures     Sudden onset of increased muscle tone. Only last a few seconds/minutes. Patient falls if standing  

Sodium valproate

Women able to have children - lamotrigine

Atonic seizures ("drop attacks")     Sudden loss of muscle tone. Often resulting in a fall. May indicate Lennox-Gastaut syndrome   Same as tonic seizures
Absence seizures More common in children   Becomes blank and stares into space then abruptly returns to normal. Unaware. 10-20 seconds Usually stop with as they grow older Ethosuximide
Infantile spasms (West syndrome) Most common in children Hypsarrhythmia on EEG It presents with clusters of full-body spasms It is associated with developmental regression and has a poor prognosis. . Treatment is with ACTH and vigabatrin
Febrile convulsions Occur in children (6month - 5 year) High fever Not caused by epilepsy or other neurological pathology One in three will have another febrile convulsion. They slightly increase the risk of developing epilepsy. Reduce fever

 

Levofloxacin (quinolones) lowers the seizure threshold

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