#Antibiotic #Drug

Doxycycline

evan Jan. 20, 2024

Drug Class	Tetracycline
Mechanism	Bacteriostatic - inhibit protein synthesis
Typical Dose	500mg BD
Indications	Chlamydia Rickettsia Refractory UTI HAP Chronic respiratory exacerbation Cellulitis/diabetic foot infection/leg ulcer Rosacea Syphilis Pelvic inflammatory disease Lyme disease Malaria/anthrax
Contra-indications	Pregnancy
Side-effects	Visual disturbances + neuro symptoms, black bones/teeth (tetracyclines), Henoch-Schonlein purpura, skin reactions, N&V, diarrhoea
Interactions	Carbamazepine/phenytoin: ↑ doxycycline metabolism Methotrexate: ↑ methotrexate toxicity
Elimination
Additional Notes