#Cardiovascular #Drug

Diltiazem

evan April 8, 2024

Drug Class	Calcium channel blocker
Mechanism	Interfere with the inward movement of calcium ions into cells relaxation of vascular smooth muscle ↓ myocardial contractility ↓ conduction at AV node, ↑ refractory period ↓ afterload and HR - ↓ oxygen consumption
Typical Dose	60,90,120,240,300mg
Indications	Angina HTN Dysrhythmias (SVT resolution instead of adenosine?)
Contra-indications	Severe bradycardia HF 2nd/3rd degree heart block Pregnancy/breast feeding
Side-effects	Headache, nausea, dizziness, hypotension, bradycardia
Interactions	Anti-arrhythmics: ↑ myocardia depression Beta blockers: ↑ risk of AV block/bradycardia Cyclosporin: ↑ plasma concentration Digoxin: ↑ plasma concentration Theophylline: ↑ effects
Elimination
Additional Notes	Can be used in Prinzmetal's angina. Extensive 1st pass metabolism