| Drug Class |
NSAID |
| Mechanism |
Reversible inhibition of COX-1 and COX-2 enzymes → prostaglandin synthesis |
| Typical Dose |
75-150mg OD with food |
| Indications |
- Inflammatory diseases (e.g RA), Post-op pain
- Pain
- Pyrexia
- Acute gout
|
| Contra-indications |
- Aspirin/NSAID hypersensitivity
- Severe heart failure
- Caution in elderly patients
|
| Side-effects |
GI discomfort, bleeding/ulceration, renal failure |
| Interactions |
- ACE inhibitors: ↑ risk of renal impairment
- SSRIs: ↑ risk of bleeding
- B blockers/CCBS: NSAIDs antagonise hypotensive effects
|
| Elimination |
|
| Additional Notes |
Risk of Gi irritation - reduce with taking with food/enteric coated tablets |
ALPHA