ALPHA
#Endocrinology

Conn's syndrome

evan Jan. 21, 2024
  • Hyperaldosteronism - primary and secondary
  • Primary: adrenal cortex hyperplasia, adenoma (intrinsic)
  • Secondary - renal artery stenosis, heart failure, liver cirrhosis (elsewhere in the body)

Via the RAAS - renal retion of H2O and Na+ so high blood pressure, headache and electrolyte disturbance symptoms - muscle spasms, cardiac arrhythmias

Hypokalaemia coupled with hypertension is suggestive of primary hyperaldosteronism 

The first line investigation for this is a plasma aldosterone/renin ratio, which should show high aldosterone levels alongside low renin levels.

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