#Drug

Codeine

evan April 13, 2024

Drug Class	Opiate
Mechanism	Partial metabolic conversion to morphine - 1/6 potency
Typical Dose	30-60mg QDS for 3 days max
Indications	Mild-moderate pain Diarrhoea Cough suppression
Contra-indications	Respiratory depression Paralytic ileus Increase intracranial pressure (interferes with pupil response for neuro obs)
Side-effects	N&V, constipation, dry mouth, biliary spasm
Interactions	Alcohol: enhanced hypotensive/sedative effects Metoclopramide: antagonise effects of metoclopramide on GI tract Cimetidine: inhibits opioid metabolism
Elimination
Additional Notes	To convert dose from codeine to morphine - divide by 10 - 60mg ⇒ 6mg