#Antibiotic #Drug

Ciprofloxacin

evan April 13, 2024

Drug Class	Quinolone
Mechanism	Broad spec bactericidal abx - inhibits DNA gyrase (needed to coil and replicate bacterial DNA)
Typical Dose	500mg BD
Indications	Gram -ve infections (Salmonella, pseudomonas, campylobacter, neisseria, e coli, h. influenzae Some gram +ve Fistulating Crohn's disease Acute otitis externa Superficial bacterial eye infection (severe) Corneal ulcer RTIs Acute prostatitis Surgical prophylaxis
Contra-indications	Pregnancy Children Caution: epilepsy (lowers seizure threshold)
Side-effects	Common: common ones Corneal deposits (reversible after completion of treatment) Arthropathy in children
Interactions	Cyclosporin: ↑ risk of nephrotoxicity Theophylline: ↑ risk of convulsion NSAIDs: ↑ risk of convulsion Warfarin: ↑ antocoagulant effects
Elimination
Additional Notes	Clinically used in UTIs, resp and GI tract infections, gonorrhea and septicaemia.