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#Drug #Neurology

Carbamazepine

evan April 10, 2024
Drug Class Anti-convulsant
Mechanism GABA-mediated inhibitory transmission in the CNS 
Typical Dose 100-200mg
Indications
  • Generalised tonic-clonic siezures
  • Partial seizures
  • Trigeminal neuralgia/chronic neurogenic pain
  • Biopolar prophylaxis
  • Adjunct in alcohol withdrawal 
Contra-indications
  • History of bone marrow depression
  • AV node conduction abnormalities
  • Porphyria
Side-effects

Common: drowsiness, ataxia, blurred vision, confusion

 

Rarely: agranulocytosis, thrombocytopenia
Interactions

Clarithromycin: carbamazepine metabolism slowed

Induce Cytochrome P450 - so anything interacts with that
Elimination  
Additional Notes  

Comments

evan

Carbamazepine causes increase in antidiuretic hormone leading to hyponatremia

April 13, 2024, 5:39 p.m.