#Cardiovascular #Drug

Bendroflumethiazide

evan April 8, 2024

Drug Class	Thiazide diuretic
Mechanism	Inhibits Na/Cl reabsorption in distal tubules Stimulate K excretion further down distal tubule
Typical Dose	2.5-10mg PO OD in the morning
Indications	Oedema HTN Prophylaxis of Ca2+ containing renal stones
Contra-indications	Refractory hypokalaemia/hyponatremia/hypercalcaemia Addision's disease Caution: gout, diabetes, SLE
Side-effects	↓ K+ ↑ Ca2+ ↓ Mg2+, ↑ urate (± gout). Postural hypotension Altered plasma lipid concentrations
Interactions	Digoxin - hypokalaemia Lithium - decreased excretion
Elimination
Additional Notes	Initial decrease in fluid volume and CO but long term the decrease in BP is due to lower peripheral vascular resistance