#Cardiovascular #Drug

Atenolol

evan April 8, 2024

Drug Class	Beta blocker
Mechanism	Acts on β1 receptors in the heart ↓ HR and force of contraction - ↓ work load ↓ rennin production by kidneys - anti-HNT ↓ conduction/AP initiation in heart - anti-arrhythmic effect
Typical Dose	25-100mg OD
Indications	HTN Angina Supraventricular dysrhythmias MI prophylaxis Migraine prophylaxis
Contra-indications	Asthma, HF, 2nd/3rd degree heart block, bradycardia, COPD
Side-effects	Lethargy Bradycardia AV block
Interactions	Do not use with diltiazem or verapamil (CCBs) as increased risk of bradycardia - use an α blocker instead Insulin - masks symptoms of hypoglycaemia
Elimination	50% urine 50% faeces
Additional Notes	Atenolol selective for β1 receptors except in high doses