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Ampicillin and amoxicillin should be avoided in patients with pharyngitis when glandular fever is considered a possibility as it may cause a maculopapular rash due to the glandular fever, which may be mistaken for an allergic reaction
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Antibiotic treatment is not routinely indicated for pharyngitis and glandular fever.
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Phenoxymethylpenicillin (penicillin V) may substitute amoxicillin/ampicillin in cases when antibiotic therapy is desired.