#Cardiovascular #Drug

Amiodarone

evan April 8, 2024

Drug Class	Anti-dysrhythmic (Class III)
Mechanism	Prolongs refractory period in all parts of conduction system - ↓ speed of conduction through the heart
Typical Dose	200-300mg
Indications	Supraventricular/ventricular arrhythmias - esp when other drugs are contra-indicated or failed V fib or pulseless VT refractory to defibrillation
Contra-indications	Sinus bradycardia SA block Sinus node dysfunction Thyroid dysfunction Iodine sensitivity (contains iodine) Pregnancy/breast feeding
Side-effects	Nausea/vomiting Jaundice Bradycardia Hypo/hyperthyroidism Sleep disturbances Pulmonary fibrosis Corneal opacities and optic neuritis
Interactions	Beta blockers: ↑ risk of bradycardia/AV block/myocardial depression Digoxin: increased risk of toxicity (can be used for the same thing, so not sure when to give both) Diltiazem/verapamil: ↑ risk of bradycardia/AV block/myocardial depression (can also be used for cardioversion)
Elimination
Additional Notes	½ life of 36 days - interactions can occur after stopping treatment. Monitor thyroid, liver and lung function every 6 months